MAMMARY-TUMOR INHIBITING PROPERTIES OF THE (S,S)-CONFIGURATED [1,2-BIS(4-HYDROXYPHENYL)ETHYLENEDIAMINE]DICHLOROPLATINUM(II) COMPLEX

被引：13
|
作者：
SPRUSS, T [1 ]
GUST, R [1 ]
MULLER, R [1 ]
ENGEL, J [1 ]
SCHONENBERGER, H [1 ]
机构：
[1] ASTA PHARMA AG,W-6000 FRANKFURT 1,GERMANY
来源：
ARCHIV DER PHARMAZIE | 1990年 / 323卷 / 02期
关键词：
D O I：
10.1002/ardp.19903230209
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Mammatumor hemmende Eigenschaften des S,S‐konfigurierten [1,2‐Bis(4‐hydroxyphenyl)ethylendiamin] dichloroplatin(II)‐Complexes [(S,S)‐1,2‐Bis(4‐hydroxyphenyl)ethylendiamin]dichloroplatin)platin(II) zeigt einen starken, Dosis‐abhängigen Effekt am hormonabhängigen MXT‐Mammacarcinom der Maus. Die R,R/S,S‐konfigurierte Verbindung ist deutlich schwächer wirksam.
引用
收藏
页码：99 / 102
页数：4
相关论文
共 50 条
  • [1] STEREOISOMERIC [1,2-BIS(3-HYDROXYPHENYL)ETHYLENEDIAMINE]PLATINUM(II) COMPLEXES .3. EVALUATION OF THE MAMMARY-TUMOR INHIBITING PROPERTIES
    SCHERTL, S
    GUST, R
    MULLER, R
    SPRUSS, T
    SCHONENBERGER, H
    ARCHIV DER PHARMAZIE, 1992, 325 (02) : 113 - 118
  • [2] TUMOR-INHIBITING PROPERTIES OF STEREOISOMERIC [1,2-BIS(3-HYDROXYPHENYL)ETHYLENEDIAMINE]DICHLOROPLATINUM(II)-COMPLEXES .1. SYNTHESIS
    JENNERWEIN, M
    GUST, R
    MULLER, R
    SCHONENBERGER, H
    ENGEL, J
    BERGER, MR
    SCHMAHL, D
    SEEBER, S
    OSIEKA, R
    ATASSI, G
    MARECHALDEBOCK, D
    ARCHIV DER PHARMAZIE, 1989, 322 (01) : 25 - 29
  • [3] TUMOR-INHIBITING [1,2-BIS(FLUOROPHENYL)ETHYLENEDIAMINE]PLATINUM(II) COMPLEXES .3. EVALUATION OF THE MAMMARY-TUMOR INHIBITING PROPERTIES
    REILE, H
    SPRUSS, T
    MULLER, R
    GUST, R
    BERNHARDT, G
    SCHONENBERGER, H
    ARCHIV DER PHARMAZIE, 1990, 323 (05) : 301 - 306
  • [4] ANTITUMOR-ACTIVITY OF ORTHO-SUBSTITUTED [1,2-BIS(4-HYDROXYPHENYL)ETHYLENEDIAMINE]DICHLOROPLATINUM(II)-COMPLEXES AND THEIR METHYL ETHERS
    KARL, J
    SCHONENBERGER, H
    ARCHIV DER PHARMAZIE, 1988, 321 (07) : 405 - 410
  • [5] TUMOR-INHIBITING [1,2-BIS(DIFLUOROPHENYL)ETHYLENEDIAMINE]-DICHLOROPLATINUM(II) COMPLEXES .1. SYNTHESIS
    MULLER, R
    SCHICKANEDER, E
    JENNERWEIN, M
    REILE, H
    SPRUSS, T
    ENGEL, J
    SCHONENBERGER, H
    ARCHIV DER PHARMAZIE, 1991, 324 (02) : 115 - 120
  • [6] DIFFERENT RESPONSE OF MURINE AND HUMAN MAMMARY-TUMOR MODELS TO A SERIES OF DIASTEREOISOMERIC [1,2-BIS(DIFLUOROPHENYL) ETHYLENEDIAMINE]DICHLOROPLATINUM(II) COMPLEXES
    SPRUSS, T
    BERNHARDT, G
    SCHICKANEDER, E
    SCHONENBERGER, H
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1991, 117 (05) : 435 - 443
  • [7] RING-SUBSTITUTED [1,2-BIS(4-HYDROXYPHENYL)ETHYLENEDIAMINE]DICHLOROPLATINUM(II) COMPLEXES - COMPOUNDS WITH A SELECTIVE EFFECT ON THE HORMONE-DEPENDENT MAMMARY-CARCINOMA
    KARL, J
    GUST, R
    SPRUSS, T
    SCHNEIDER, MR
    SCHONENBERGER, H
    ENGEL, J
    WROBEL, KH
    LUX, F
    HAEBERLIN, ST
    JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (01) : 72 - 83
  • [8] REDUCTION OF THE ESTROGENIC SIDE-EFFECTS OF THE MAMMARY TUMOR-INHIBITING DRUG [1,2-BIS(2,6-DICHLORO-4-HYDROXYPHENYL)-ETHYLENEDIAMINE]DICHLOROPLATINUM(II) BY VARIATION OF RING SUBSTITUENTS
    GUST, R
    KARL, J
    FADERL, M
    SCHONENBERGER, H
    ARCHIV DER PHARMAZIE, 1995, 328 (05) : 457 - 463
  • [9] N,N'-DIALKYL-1,2-BIS(HYDROXYPHENYL)ETHYLENEDIAMINES AND N,N'-DIALKYL-4,5-BIS(4-HYDROXYPHENYL)IMIDAZOLIDINES - SYNTHESES AND EVALUATION OF THEIR MAMMARY-TUMOR INHIBITING ACTIVITY
    VONANGERER, E
    EGGINGER, G
    KRANZFELDER, G
    BERNHAUER, H
    SCHONENBERGER, H
    JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (07) : 832 - 837
  • [10] TUMOR-INHIBITING [1,2-BIS(FLUOROPHENYL)ETHYLENEDIAMINE]PLATINUM(II) COMPLEXES .5. SYNTHESIS AND EVALUATION OF ENANTIOMERIC [1,2-BIS-(4-FLUOROPHENYL)ETHYLENEDIAMINE]DICHLOROPLATINUM(II) COMPLEXES
    VOMORDE, HD
    REILE, H
    MULLER, R
    GUST, R
    BERNHARDT, G
    SPRUSS, T
    SCHONENBERGER, H
    BURGEMEISTER, T
    MANNSCHRECK, A
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1990, 116 (05) : 434 - 438
12345