QUANTITATIVE NONDESTRUCTIVE DETERMINATION OF SALICYLIC-ACID ACETATE IN ASPIRIN TABLETS BY RAMAN-SPECTROSCOPY

Laser Raman spectroscopy was used for the quantitative determination of aspirin in aspirin-maize starch tablets. A calibration curve was constructed from spectra obtained from tablets with known quantities of aspirin and starch. The calibration curve is given from the relationship: I-552/I-478 = (W-aspirin/W-starch) x 4.21, where I-552 and I-478 and the relative Raman intensities for the 552 and 478 cm(-1) Raman shift, respectively. W-aspirin and W-starch represent the weight of aspirin and starch in a pellet.