EFFECT OF TOPICAL CORTICOSTEROIDS ON HUMAN SEBUM PRODUCTION ASSESSED BY 2 DIFFERENT METHODS

被引：17

作者：

LEVEQUE, JL ^{[1
]}

PIERARDFRANCHIMONT, C ^{[1
]}

DERIGAL, J ^{[1
]}

SAINTLEGER, D ^{[1
]}

PIERARD, GE ^{[1
]}

机构：

[1] CHU SART TILMAN,SERV DERMATOPATHOL,B-4000 LIEGE,BELGIUM

来源：

ARCHIVES OF DERMATOLOGICAL RESEARCH | 1991年 / 283卷 / 06期

关键词：

CORTICOSTEROIDS; SEBUM; ATROPHY; LIPOMETRE; SEBUTAPE;

D O I：

10.1007/BF00371818

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Topical corticosteroids are widely used in cutaneous diseases. Although their mode of action on different skin compartments has been documented, little is known about their effects on the human sebaceous gland. We investigated the effects of two corticosteroids of differing potency on the excretion of sebum by means of two validated techniques: the Sebutape and the Lipometre. This study was conducted on the forehead skin of normal healthy subjects. The results obtained with both techniques correlated well. The application of both corticosteroids during a 4-week period led to a significant decrease in sebum excretion. This decrease was more pronounced with the more potent corticosteroid (Dermovate). In the light of these findings, it is likely that topical corticosteroids exert an anti-proliferative action upon the sebaceous cells in a similar manner to their effect in other skin compartments.

引用

页码：372 / 376

页数：5

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