Global DNA methylation and depression: Preliminary result from community based epidemiological study

被引：0

作者：

Rawat, Suchita ^{[1
]}

Kaur, Gurjinder ^{[2
]}

Yadav, Suniti ^{[1
]}

Khan, Maroof Ahmad ^{[3
]}

Saraswathy, Kallur Nava ^{[1
]}

机构：

[1] Univ Delhi, Dept Anthropol, Delhi 110007, India

[2] Panjab Univ, Dept Anthropol, Chandigarh 160014, India

[3] All India Inst Med Sci, Dept Biostat, Delhi 110029, India

来源：

META GENE | 2018年 / 15卷

关键词：

Global DNA hypomethylation; Depression; Suicide ideation;

D O I：

10.1016/j.mgene.2017.12.004

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The present study aims to investigate the role of Global DNA Methylation in Depression. A total of 368 individuals (118 males and 250 females) were screened for depression using PHQ9 (Patient Health Questionnaire 9) and 5-mc% (5-methyl cytosine) content of Peripheral Leucocytes DNA was measured by enzyme linked calorimetric based MethyFlash T methylated DNA quantification kit. Among individuals with depression a lower Global DNA methylation (though not significant) in terms of 5-mc% (5-methyl cytosine) content was observed compared to individuals without depression.

引用

页码：84 / 86

页数：3

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