Global DNA methylation and depression: Preliminary result from community based epidemiological study

被引：0
|
作者：
Rawat, Suchita [1 ]
Kaur, Gurjinder [2 ]
Yadav, Suniti [1 ]
Khan, Maroof Ahmad [3 ]
Saraswathy, Kallur Nava [1 ]
机构：
[1] Univ Delhi, Dept Anthropol, Delhi 110007, India
[2] Panjab Univ, Dept Anthropol, Chandigarh 160014, India
[3] All India Inst Med Sci, Dept Biostat, Delhi 110029, India
来源：
META GENE | 2018年 / 15卷
关键词：
Global DNA hypomethylation; Depression; Suicide ideation;
D O I：
10.1016/j.mgene.2017.12.004
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The present study aims to investigate the role of Global DNA Methylation in Depression. A total of 368 individuals (118 males and 250 females) were screened for depression using PHQ9 (Patient Health Questionnaire 9) and 5-mc% (5-methyl cytosine) content of Peripheral Leucocytes DNA was measured by enzyme linked calorimetric based MethyFlash T methylated DNA quantification kit. Among individuals with depression a lower Global DNA methylation (though not significant) in terms of 5-mc% (5-methyl cytosine) content was observed compared to individuals without depression.
引用
收藏
页码：84 / 86
页数：3
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