SYNTHESIS AND ANTI-VIRAL ACTIVITY OF SOME PHOSPHATES OF BROAD-SPECTRUM ANTI-VIRAL NUCLEOSIDE, 1-BETA-D-RIBOFURANOSYL-1,2,4-TRIAZOLE-3-CARBOXAMIDE (RIBAVIRIN)

被引：40

作者：

ALLEN, LB

BOSWELL, KH

KHWAJA, TA

MEYER, RB

SIDWELL, RW

WITKOWSKI, JT

CHRISTENSEN, LF

ROBINS, RK

机构：

[1] BRIGHAM YOUNG UNIV, DEPT CHEM, PROVO, UT 84602 USA

[2] ICN PHARMACEUT INC, IRVINE, CA 92664 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1978年 / 21卷 / 08期

关键词：

D O I：

10.1021/jm00206a005

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

1-.beta.-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide 5''-phosphate was prepared and converted into the following derivatives: the 5''-phosphoramidate, the 5''-diphosphate, the 5''-triphosphate and the cyclic 3'',5''-phosphate. The cyclic 2'',3''-phosphate was prepared from the parent nucleoside, 1-.beta.-D-ribofuranosyl-1,2,4-triazole-3-carboxamide and was opened to the 2''(3'')-phosphate. These compounds exhibited significant antiviral activity against several viruses in cell culture. Ribovirin 5''-phosphate was effective when tested against lethal infections in mice caused by influenza A2, influenza B and murine hepatitis viruses.

引用

页码：742 / 746

页数：5

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