MOLECULAR-CLONING OF RAT RAC PROTEIN KINASE-ALPHA AND KINASE-BETA AND THEIR ASSOCIATION WITH PROTEIN-KINASE-C-ZETA

被引：68

作者：

KONISHI, H ^{[1
]}

SHINOMURA, T ^{[1
]}

KURODA, S ^{[1
]}

ONO, Y ^{[1
]}

KIKKAWA, U ^{[1
]}

机构：

[1] KOBE UNIV, FAC SCI, DEPT BIOL, NADA KU, KOBE 657, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 205卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.2738

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

cDNAs of RAC protein kinases (RAC-PK) alpha and beta were cloned from a rat testis cDNA library. The predicted open reading frames encode 480 and 481 amino acids of RAC-PK alpha and beta, respectively, and the rat RAC-PK alpha and beta have sequences conserved among different mammalian species such as the pleckstrin homology domain at their aminoterminal region and the protein-serine/threonine kinase catalytic domain at their carboxy-terminal region. RNA blot analysis showed wide distribution of two RAC-PK in rat tissues. Immunoprecipitation analysis revealed that RAC-PK alpha and beta associate with protein kinase C zeta through the pleckstrin homology domain in vitro, suggesting the interaction between RAC-PK and protein kinase C. (C) 1994 Academic Press, Inc.

引用

页码：817 / 825

页数：9

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