LINKAGE ANALYSIS OF EARLY-ONSET BREAST AND OVARIAN-CANCER FAMILIES, WITH MARKERS ON THE LONG ARM OF CHROMOSOME-17

被引：0

作者：

SPURR, NK

KELSELL, DP

BLACK, DM

MURDAY, VA

TURNER, G

CROCKFORD, GP

SOLOMON, E

CARTWRIGHT, RA

BISHOP, DT

机构：

[1] IMPERIAL CANC RES FUND,SOMAT CELL GENET LAB,LONDON WC2A 3PX,ENGLAND

[2] IMPERIAL CANC RES FUND,GENET EPIDEMIOL LAB,LEEDS,ENGLAND

来源：

AMERICAN JOURNAL OF HUMAN GENETICS | 1993年 / 52卷 / 04期

关键词：

D O I：

暂无

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have conducted linkage analysis in 16 breast cancer families, 13 of which are classified as site-specific breast cancer families and 3 of which are classified as breast-ovary families. Linkage analysis has largely focused on a single extended breast-ovary family. Analysis of all families combined shows significant evidence for linkage to 17q (LOD = 3.63 at theta = .0, for linkage to NME1), confirming the observations of Hall et al. and Narod et al. Many families were consistent with linkage, but their limited size and informativeness precluded confirmation of linkage. A putative recombinant in a breast-ovary family suggests that BRCA1 is distal to D17S250.

引用

页码：777 / 785

页数：9

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