TROPONIN ISOFORM DEPENDENT PH-DEPENDENCE OF THE CA2+-ACTIVATED MYOFIBRILLAR ATPASE ACTIVITY OF AVIAN SLOW AND FAST SKELETAL-MUSCLES

被引：6
|
作者：
KAWASHIMA, A
MORIMOTO, S
SUZUKI, A
SHIRAISHI, F
OHTSUKI, I
机构：
[1] KYUSHU UNIV,FAC MED,DEPT PHARMACOL,HIGASHI KU,FUKUOKA 812,JAPAN
[2] KYUSHU UNIV,FAC MED,DEPT ORTHOPED SURG,HIGASHI KU,FUKUOKA 812,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 207卷 / 02期
关键词：
D O I：
10.1006/bbrc.1995.1228
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effects of acidic pH were examined on the Ca2+-sensitive ATPase activity of chicken fast and slow skeletal muscle myofibrils. In both types of myofibrils the Ca2+-sensitivity declined on decreasing pH from 7.4 to 6.2, but the slow skeletal muscle myofibrils were found to exhibit a Ca2+-sensitive ATPase activity which was more resistant to acidic pH compared to the fast skeletal muscle myofibrils. The results obtained by using a novel method for replacing whole troponin complex in myofibrils provide the first evidence that troponin is responsible for this higher resistibility of slow skeletal muscle myofibrils to acidosis. (C) 1995 Academic Press, Inc.
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页码：585 / 592
页数：8
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