SYNTHESIS OF NUCLEOSIDE 5'-DEOXY-5'-DIFLUOROMETHYLPHOSPHONATES

被引：29
|
作者：
MATULICADAMIC, J
USMAN, N
机构：
[1] Department of Chemistry, Biochemistry Ribozyme Pharmaceuticals Inc., Boulder, CO 80301
来源：
TETRAHEDRON LETTERS | 1994年 / 35卷 / 20期
关键词：
D O I：
10.1016/S0040-4039(00)76871-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
1-O-Acetyl-2,3-di-O-benzoyl-D-ribofuranose 5-deoxy-5-difluoromethylphosphonate was synthesized in three steps from 1-O-methyl-2,3-O-isopropylidene-beta-D-ribofuranose 5-deoxy-5-difluoromethylphosphonate. Condensation of this suitably derivatized sugar with silylated pyrimidines and purines afforded novel nucleoside 5'-deoxy-5'-difluoromethylphosphonates.
引用
收藏
页码：3227 / 3230
页数：4
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