AN IMMUNOHISTOLOGICAL DEMONSTRATION OF C-ERBB-2 ONCOPROTEIN EXPRESSION IN PRIMARY UROTHELIAL BLADDER-CANCER

被引：25
|
作者：
GARDINER, RA
SAMARATUNGA, MLTH
WALSH, MD
SEYMOUR, GJ
LAVIN, MF
机构：
[1] QUEENSLAND INST MED RES,HERSTON,QLD 4006,AUSTRALIA
[2] UNIV QUEENSLAND,DEPT ORAL BIOL,HERSTON,AUSTRALIA
[3] ROYAL BRISBANE HOSP,DEPT PATHOL,HERSTON,AUSTRALIA
来源：
UROLOGICAL RESEARCH | 1992年 / 20卷 / 02期
关键词：
D O I：
10.1007/BF00296522
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Sections of formalin-fixed, paraffin-blocked tissue from 116 primary transitional cell carcinomas were stained immunohistochemically using a polyclonal antibody against the c-erbB-2 oncoprotein. Positive staining of cell membranes, known to correlate with gene amplification, was seen in 22 (19%) of the 116, with variable staining from tumour to tumour and within tumours themselves. Consistent with its mooted value as a prognosticator in bladder cancer, the c-erbB-2 oncoprotein was detected in 13 (of 40) grade III and 9 of the 26 muscle-invasive tumours examined compared to 1 (of 25) grade I and 6 (of 66) mucosa only (pTa) lesions. These results support further examination of c-erbB-2 expression in bladder cancer.
引用
收藏
页码：117 / 120
页数：4
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