USE OF MONOCLONAL-ANTIBODY 17.13 IN THE DIAGNOSIS OF HUMAN ORAL SQUAMOUS-CELL CARCINOMA

被引：6
|
作者：
MIGLIORATI, CA
RANKEN, R
KAPLAN, M
SILVERMAN, S
机构：
[1] UNIV FLORIDA,COLL DENT,DEPT ORAL DIAGNOST SCI ORAL MED,GAINESVILLE,FL 32611
[2] INTEK DIAGNOST INC,MILBRAE,CA
[3] UNIV CALIF SAN FRANCISCO,SCH MED,DEPT OTOLARYNGOL,SAN FRANCISCO,CA 94143
来源：
JOURNAL OF ORAL PATHOLOGY & MEDICINE | 1990年 / 19卷 / 09期
关键词：
cancer diagnosis; monoclonal antibodies; mouth; neoplasms; oral cancer; oral pathology;
D O I：
10.1111/j.1600-0714.1990.tb00870.x
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
We assessed the ability of monoclonal antibody (MAb) 17.13 to react with human oral squamous cell carcinoma (OSCC) and other oral tissues. MAb 17.13 was reacted with acetone‐fixed, serial frozen sections of 21 Oscc, 7 fibromas, 2 squamous papillomas, 1 melanosis and 3 normal oral mucosa, by means of an avidin‐biotin‐immunoperoxidase assay. Twenty‐one of 21 tumors (100% sensitivity) reacted strongly with MAb 17.13, with a homogenous staining pattern. Individual tumor cells could be clearly seen, improving the detection of microinvasion or borderline lesions. The epithelium of benign lesions and normal oral mucosa showed staining of the basal cells only. We conclude MAb 17.13 could be used as an accurate diagnostic tool for OSCC. Copyright © 1990, Wiley Blackwell. All rights reserved
引用
收藏
页码：414 / 418
页数：5
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