STRUCTURE-ACTIVITY-RELATIONSHIPS OF SYNTHETIC METHYL GLYCYRRHETATE GLYCOSIDES

被引：7
|
作者：
TAKECHI, M
TANAKA, Y
机构：
[1] Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka
来源：
PHYTOCHEMISTRY | 1993年 / 32卷 / 05期
关键词：
STRUCTURE ACTIVITY RELATIONSHIPS; HEMOLYSIS; ANTIFUNGAL ACTIVITY; ANTIBACTERIAL ACTIVITY; SYNTHETIC GLYCOSIDES; GLYCYRRHETIC ACID; SAPONIN;
D O I：
10.1016/S0031-9422(00)95086-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Of 15 synthetic methyl glycyrrhetate glycosides, the monoglycosides having CH2OH-6 or Me-6 in their sugar moieties and the diglycosides having a (1-->4) linkage between the sugar residues showed higher haemolytic activities than the others. The beta-maltoside and beta-lactoside exhibited much stronger antifungal activities against Trichophyton mentagrophytes than the others. However, none of them exhibited antibacterial activity against Staphylococcus aureus or Bacillus subtilis.
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页码：1173 / 1175
页数：3
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