PHARMACOKINETICS OF CEFOTAXIME AND DESACETYLCEFOTAXIME IN THE YOUNG

被引：13

作者：

KEARNS, GL ^{[1
]}

YOUNG, RA ^{[1
]}

机构：

[1] UNIV ARKANSAS MED SCI HOSP, DEPT PEDIAT, LITTLE ROCK, AR 72205 USA

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 1995年 / 22卷 / 1-2期

关键词：

D O I：

10.1016/0732-8893(95)00052-C

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Available information on the pharmacokinetics of cefotaxime (CTX) and desacetylcefotaxime (dCTX) indicates that their disposition depends on development, with the greatest changes occurring during the Ist year of life. To a great extent, these changes reside with the acquisition of renal function (e.g., both glomerular filtration and active tubular secretion) during the Ist year of life. When the impact of development on CTX and dCTX disposition is considered, it is apparent that age-appropriate pharmacokinetic data can be used to individualize CTX dosing regimens according to age. Also, alternative dosing regimens that have been proven to be both safe and effective can be justified.

引用

页码：97 / 104

页数：8

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