AMINO-ACID CONJUGATES OF THE HAPTEN 2-PHENYL-4-ETHOXYMETHYLENE-5(4H)-OXAZOLONE - SYNTHESIS AND CONFIRMATION OF STRUCTURE

被引：0
|
作者：
BENOITON, NL [1 ]
HUDECZ, F [1 ]
CHEN, FMF [1 ]
机构：
[1] HUNGARIAN ACAD SCI, PEPTIDE CHEM RES GRP, BUDAPEST, HUNGARY
来源：
INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH | 1995年 / 45卷 / 03期
关键词：
AMINO-ACID CONJUGATES; AMINOLYSIS; E-VERTICAL-BAR-Z ISOMERS; NUCLEAR MAGNETIC RESONANCE; OXAZOLONE CONJUGATES; 2-PHENYLOXAZOLE-4-CARBOXYMETHYLAMIDE 2-PHENYL-4-(CARBOXYALKYLAMINO)METHYLENE-5(4H)-OXAZOLONES;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
2-Phenyl-4-ethoxymethylene-5(4H)-oxazolo (PhOx=CHOEt) was reacted with methylamine, and 2-phenyloxazole-4-carboxylic acid was coupled with methylamine. The spectroscopic properties of the two products were compared in order to confirm that aminolysis of PhOx=CHOEt occurs by displacement of the ethoxy group to give 2-phenyl-4-(substituted-methylene)-5(4H) and not by attack at the ox oxazolone-carbonyl followed by rearrangement to give 2-phenyloxazole-4-carboramides. Ten crystalline conjugates were prepared and characterized by reacting PhOx=CHOEt with an excess of unprotected di- and trifunctional amino acid anions followed by purification by washing them with hydrochloric acid. (C) Munksgaard 1995.
引用
收藏
页码：266 / 271
页数：6
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