DEVELOPMENT AND PROLIFERATION OF LYMPHOCYTES IN MICE DEFICIENT FOR BOTH INTERLEUKIN-2 AND INTERLEUKIN-4

被引：129

作者：

SADLACK, B

KUHN, R

SCHORLE, H

RAJEWSKY, K

MULLER, W

HORAK, I

机构：

[1] UNIV WURZBURG, INST VIROL & IMMUNOBIOL, D-97078 WURZBURG, GERMANY

[2] UNIV COLOGNE, INST GENET, COLOGNE, GERMANY

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1994年 / 24卷 / 01期

关键词：

INTERLEUKIN-2; INTERLEUKIN-4; DEVELOPMENT AND PROLIFERATION OF LYMPHOCYTES; CYTOKINES; KNOCK-OUT MICE;

D O I：

10.1002/eji.1830240144

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin (IL)-2 and IL-4 are considered as important regulators of growth and differentiation of lymphocytes. We report that in mice made deficient for both IL-2 and IL-4 by gene targeting all major T cell subsets and B cells were normal, indicating that IL-2 and IL-4 are not essential for development of the immune system. Paradoxically, proliferation of T cells was increased in both IL-2- and IL-4-deficient homozygous mice.

引用

下载

页码：281 / 284

页数：4

共 50 条

[21] ANALYSIS OF INTERLEUKIN-2, INTERLEUKIN-4 AND INTERLEUKIN-5 PRODUCTION IN MITOGEN STIMULATED MURINE LYMPHOCYTES BY INSITU HYBRIDIZATION
CARDELL, S
SANDER, B
MOLLER, G
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1989, 30 (05) : 633 - 633
[22] EVIDENCE FOR INTRATHYMIC REGULATION OF T-CELL DEVELOPMENT BY INTERLEUKIN-2 AND INTERLEUKIN-4
TANNISHTHA
FLAVELL, RA
CARDING, SR
JOURNAL OF IMMUNOLOGY, 1993, 150 (08): : A44 - A44
[23] INTERLEUKIN-4 REGULATES THE INTERLEUKIN-2 RECEPTORS ON HUMAN PERIPHERAL-BLOOD LYMPHOCYTES-B
TOMIZAWA, K
ISHIZAKA, A
KOJIMA, K
NAKANISHI, M
SAKIYAMA, Y
MATSUMOTO, S
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1991, 83 (03): : 492 - 496
[24] INDUCTION OF PROLIFERATION AND INTERLEUKIN-2 RECEPTORS ON RESTING HUMAN-LYMPHOCYTES BY INTERLEUKIN-2 AND INTERLEUKIN-1
KERN, J
TAYLOR, DS
NOWELL, PC
JOURNAL OF LEUKOCYTE BIOLOGY, 1985, 37 (06) : 716 - 717
[25] INTERLEUKIN-4 DEFICIENT MICE AND ALLERGIC AIRWAY INFLAMMATION
BRUSSELLE, GG
CUVELIER, CA
VANDERHEYDEN, J
TAVERNIER, JH
BLUTHMANN, H
KIPS, JC
PAUWELS, RA
JOURNAL OF CELLULAR BIOCHEMISTRY, 1993, : 87 - 87
[26] GROWTH AND AUTOLOGOUS TUMOR LYSIS BY TUMOR-INFILTRATING LYMPHOCYTES FROM METASTATIC MELANOMA EXPANDED IN INTERLEUKIN-2 OR INTERLEUKIN-2 PLUS INTERLEUKIN-4
LINDGREN, CG
THOMPSON, JA
HIGUCHI, CM
FEFER, A
JOURNAL OF IMMUNOTHERAPY, 1993, 14 (04): : 322 - 328
[27] INTERLEUKIN-4 DEFICIENT MICE AND ALLERGIC AIRWAY INFLAMMATION
BRUSSELLE, GG
CUVELIER, CA
VANDERHEYDEN, J
TAVERNIER, JH
BLUTHMANN, H
KIPS, JC
PAUWELS, RA
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1993, 91 (01) : 176 - 176
[28] INTERLEUKIN-4 INHIBITS THE PROLIFERATION BUT NOT THE DIFFERENTIATION OF ACTIVATED HUMAN B-CELLS IN RESPONSE TO INTERLEUKIN-2
BANCHEREAU, J
VANBERVLIET, B
DEFRANCE, T
LYMPHOKINE RESEARCH, 1988, 7 (03): : 308 - 308
[29] INTERLEUKIN-4 INHIBITS THE PROLIFERATION BUT NOT THE DIFFERENTIATION OF ACTIVATED HUMAN B-CELLS IN RESPONSE TO INTERLEUKIN-2
DEFRANCE, T
VANBERVLIET, B
AUBRY, JP
BANCHEREAU, J
JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 168 (04): : 1321 - 1337
[30] INTERLEUKIN-4 INHIBITS THE PROLIFERATION BUT NOT THE DIFFERENTIATION OF ACTIVATED HUMAN B-CELLS IN RESPONSE TO INTERLEUKIN-2
DEFRANCE, T
VANBERVLIET, B
BANCHEREAU, J
EXPERIMENTAL HEMATOLOGY, 1988, 16 (06) : 549 - 549

← 1 2 3 4 5 →