DEVELOPMENT AND PROLIFERATION OF LYMPHOCYTES IN MICE DEFICIENT FOR BOTH INTERLEUKIN-2 AND INTERLEUKIN-4

被引：129

作者：

SADLACK, B

KUHN, R

SCHORLE, H

RAJEWSKY, K

MULLER, W

HORAK, I

机构：

[1] UNIV WURZBURG, INST VIROL & IMMUNOBIOL, D-97078 WURZBURG, GERMANY

[2] UNIV COLOGNE, INST GENET, COLOGNE, GERMANY

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1994年 / 24卷 / 01期

关键词：

INTERLEUKIN-2; INTERLEUKIN-4; DEVELOPMENT AND PROLIFERATION OF LYMPHOCYTES; CYTOKINES; KNOCK-OUT MICE;

D O I：

10.1002/eji.1830240144

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin (IL)-2 and IL-4 are considered as important regulators of growth and differentiation of lymphocytes. We report that in mice made deficient for both IL-2 and IL-4 by gene targeting all major T cell subsets and B cells were normal, indicating that IL-2 and IL-4 are not essential for development of the immune system. Paradoxically, proliferation of T cells was increased in both IL-2- and IL-4-deficient homozygous mice.

引用

页码：281 / 284

页数：4

共 50 条

[1] DEVELOPMENT AND PROLIFERATION OF LYMPHOCYTES IN MICE DEFICIENT FOR BOTH INTERLEUKIN-2 AND INTERLEUKIN-4
SADLACK, B
KUHN, R
SCHORLE, H
RAJEWSKY, K
MULLER, W
HORAK, I
[J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, : 458 - 458
[2] ANTIVIRAL IMMUNE-RESPONSES IN MICE DEFICIENT FOR BOTH INTERLEUKIN-2 AND INTERLEUKIN-4
BACHMANN, MF
SCHORLE, H
KUHN, R
MULLER, W
HENGARTNER, H
ZINKERNAGEL, RM
HORAK, I
[J]. JOURNAL OF VIROLOGY, 1995, 69 (08) : 4842 - 4846
[3] Effect of interleukin-2 and interleukin-4 on lymphocytes from peribronchial lymphatic tissue
Or, R
Lossos, IS
Hirschfeld, E
Breuer, R
[J]. EXPERIMENTAL LUNG RESEARCH, 1996, 22 (02) : 245 - 253
[4] DIFFERENTIAL BIOASSAY OF INTERLEUKIN-2 AND INTERLEUKIN-4
HO, SN
ABRAHAM, RT
GILLIS, S
MCKEAN, DJ
[J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1987, 98 (01) : 99 - 104
[5] ANALYSIS OF INTERLEUKIN-2, INTERLEUKIN-4 AND INTERLEUKIN-5 PRODUCTION IN MURINE LYMPHOCYTES BY INSITU HYBRIDIZATION
CARDELL, S
SANDER, B
MOLLER, G
[J]. SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1990, 32 (04) : 387 - 387
[6] THE TREATMENT OF PATIENTS WITH MELANOMA USING INTERLEUKIN-2, INTERLEUKIN-4 AND TUMOR INFILTRATING LYMPHOCYTES
LOTZE, MT
[J]. HUMAN GENE THERAPY, 1992, 3 (02) : 167 - 177
[7] INTERLEUKIN-4 DOWN-REGULATES THE INTERLEUKIN-2 RESPONSIVENESS OF INTRAEPITHELIAL LYMPHOCYTES (IEL)
EBERT, EC
ROBERTS, AI
[J]. GASTROENTEROLOGY, 1995, 108 (04) : A813 - A813
[8] PRECURSOR FREQUENCY AND LYTIC SPECIFICITY OF INTERLEUKIN-2 AND INTERLEUKIN-4 RESPONSIVE MURINE LYMPHOCYTES
WIDMER, MB
VOICE, RF
CONLON, PJ
GRABSTEIN, KH
[J]. TRANSPLANTATION, 1990, 49 (04) : 743 - 748
[9] INTERLEUKIN-2, INTERFERON-GAMMA AND INTERLEUKIN-4 PRODUCTION BY LYMPHOCYTES IN THE RETINA IN EAU
BARTON, K
MCLAUCHLAN, MT
CALDER, VL
LIGHTMAN, S
[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1993, 34 (04) : 1144 - 1144
[10] INTERLEUKIN-4 COUNTERACTS THE INTERLEUKIN-2 INDUCED PROLIFERATION OF MONOCLONAL-B CELLS
KARRAY, S
DEFRANCE, T
MERLEBERAL, H
BANCHEREAU, J
DEBRE, P
GALANAUD, P
[J]. LYMPHOKINE RESEARCH, 1988, 7 (03): : 305 - 305

← 1 2 3 4 5 →