Thymic stromal lymphopoietin controls hair growth

被引：6
|
作者：
Shannon, Jessica L. [1 ,2 ]
Corcoran, David L. [3 ]
Murray, John C. [1 ]
Ziegler, Steven F. [4 ,5 ]
MacLeod, Amanda S. [1 ,2 ,6 ]
Zhang, Jennifer Y. [1 ,7 ]
机构：
[1] Duke Univ, Dept Dermatol, POB 103052, Durham, NC 27710 USA
[2] Duke Univ, Dept Immunol, Durham, NC 27710 USA
[3] Duke Univ, Genom & Computat Biol, Durham, NC 27705 USA
[4] Benaroya Res Inst, Seattle, WA 98101 USA
[5] Univ Washington, Dept Immunol, Seattle, WA 98195 USA
[6] Duke Univ, Mol Genet & Microbiol, Durham, NC 27710 USA
[7] Duke Univ, Dept Pathol, Med Ctr, Durham, NC 27710 USA
来源：
STEM CELL REPORTS | 2022年 / 17卷 / 03期
关键词：
STEM-CELLS; FOLLICLE NEOGENESIS; WOUND REPAIR; T-CELLS; SKIN; TSLP; KERATINOCYTES; INFLAMMATION; EXPRESSION; RECEPTOR;
D O I：
10.1016/j.stemcr.2022.01.017
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Skin tissue regeneration after injury involves the production and integration of signals by stem cells residing in hair follicles (HFSCs). Much remains unknown about how specific wound-derived factors modulate stem cell contribution to hair growth. We demonstrate that thymic stromal lymphopoietin (TSLP) is produced in response to skin injury and during the anagen phase of the hair cycle. Intradermal injection of TSLP promoted wound-induced hair growth (WIHG), whereas neutralizing TSLP receptor (TSLPR) inhibited WIHG. Using flow cytometry and fluorescent immunostaining, we found that TSLP promoted proliferation of transit-amplifying cells. Lgr5(creER-) mediated deletion of Tslpr in HFSCs inhibited both wound-induced and exogenous TSLP-induced hair growth. Our data highlight a novel function for TSLP in regulation of hair follicle activity during homeostasis and wound healing.
引用
收藏
页码：649 / 663
页数：15
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