SUPEROXIDE ANION-INDUCED HISTAMINE-RELEASE FROM RAT PERITONEAL MAST-CELLS

被引：0
|
作者：
AKAGI, M [1 ]
KATAKUSE, Y [1 ]
FUKUISHI, N [1 ]
KAN, T [1 ]
AKAGI, R [1 ]
机构：
[1] OKAYAMA PREFECTURAL UNIV, FAC HLTH & WELF SCI, DEPT NUTRIT SCI, OKAYAMA 700, JAPAN
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 1994年 / 17卷 / 05期
关键词：
SUPEROXIDE ANION; HISTAMINE RELEASE; RAT MAST CELL;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We investigated the properties of superoxide anion (O2-)-induced histamine release from rat peritoneal mast cells using superoxide anion radicals obtained from potassium superoxide (KO2). KO2 elicited a rapid histamine release in a dose-dependent fashion, without lactate dehydrogenase (LDH) release. The KO2-induced release was temperature- and energy-dependent. KO2 rapidly increased the intracellular free Ca2+ concentration, accompanied by a marked increase of Ca2+-uptake. These findings indicate that the increase in intracellular Ca2+ concentration is involved in the initiation of KO2-induced histamine release, and KO, could be used as an agent of O2--induced biological reactions.
引用
收藏
页码：732 / 734
页数：3
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