EFFECT OF ECDYSTERONE ON HISTAMINE-RELEASE FROM RAT PERITONEAL MAST-CELLS

被引：10
|
作者：
TAKEI, M
ENDO, K
NISHIMOTO, N
SHIOBARA, Y
INOUE, S
MATSUO, S
机构：
[1] TOKUSHIMA BUNRI UNIV,FAC PHARMACEUT SCI,YAMASHIRO,TOKUSHIMA 770,JAPAN
[2] BIOX CO LTD,SHINAGAWA KU,TOKYO 140,JAPAN
来源：
JOURNAL OF PHARMACEUTICAL SCIENCES | 1991年 / 80卷 / 04期
关键词：
D O I：
10.1002/jps.2600800403
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Ecdysterone dose-dependently inhibited anti-IgE-induced histamine release from mast cells. Moreover, the rate and extent of histamine release from mast cells induced by Concanavalin A (Con A) are significantly diminished in samples incubated with ecdysterone. Ecdysterone inhibited both the initial and gradual rise in fluorescent response by anti-IgE and Con A. The effects of ecdysterone on the fluorescence response was correlated with the inhibition of histamine release. These results suggest the possibility that the inhibition of histamine release from rat mast cells by ecdysterone might be due to inhibition of Ca2+ mobilization from intracellular Ca2+ storage.
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收藏
页码：309 / 310
页数：2
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