HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR THE ENANTIOMERIC SEPARATION OF THE CHIRAL METABOLITES OF MIDAZOLAM

被引：1
|
作者：
DREWE, J
KUSTERS, E
机构：
[1] UNIV CLIN BASEL,KANTONSSPITAL,DEPT RES,CH-4031 BASEL,SWITZERLAND
[2] SANDOZ PHARMA LTD,CHEM PROC & RES DEV,CH-4002 BASEL,SWITZERLAND
来源：
JOURNAL OF CHROMATOGRAPHY | 1992年 / 609卷 / 1-2期
关键词：
D O I：
10.1016/0021-9673(92)80186-X
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The enantiomeric resolution of the chiral metabolites of midazolam, 4-hydroxymidazolam and 1,4-dihydroxymidazolam, by high-performance liquid chromatography on a chiral stationary phase containing immobilized ovomucoid is described (no derivatization was necessary). Large separation factors (up to alpha = 2.9) were obtained by varying the type and amount of organic modifier in the mobile phase. The system so far developed is recommended for monitoring possible differences in the stereoselective metabolism of midazolam.
引用
收藏
页码：395 / 398
页数：4
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