THE INHIBITORY-ACTION OF FLUCONAZOLE ON YEAST-TO-MYCELIAL PHASE CONVERSION IN CANDIDA-ALBICANS

被引：5
|
作者：
SIMONETTI, N
DAURIA, FD
STRIPPOLI, V
SIMONETTI, G
机构：
[1] Institute of Microbiology, Department of Pharmacy, ‘La Sapienza’ University of Rome, Rome
来源：
DRUG INVESTIGATION | 1992年 / 4卷 / 01期
关键词：
D O I：
10.1007/BF03258373
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The ability of fluconazole, a bis-triazole antifungal agent, to inhibit conversion of Candida albicans from the yeast (Y) to the pathogenic mycelial (M) form was studied under various in vitro cultural conditions. In growth-supporting media, fluconazole was able to inhibit Y to M conversion of the test organism at concentrations below those required to inhibit Y phase growth. Under nongrowth-supporting conditions (N-acetylglucosamine solution) fluconazole had only a small effect on Y to M conversion.
引用
收藏
页码：15 / 19
页数：5
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