INHIBITORY EFFECT OF GOSSYPOL ON HUMAN CHORIONIC-GONADOTROPIN (HCG)-INDUCED PROGESTERONE SECRETION IN CULTURED BOVINE LUTEAL CELLS

被引：18
|
作者：
GU, Y [1 ]
CHANG, CJG [1 ]
RIKIHISA, Y [1 ]
LIN, YC [1 ]
机构：
[1] OHIO STATE UNIV,COLL VET MED,DEPT VET PATHOBIOL,COLUMBUS,OH 43210
来源：
LIFE SCIENCES | 1990年 / 47卷 / 05期
关键词：
D O I：
10.1016/0024-3205(90)90298-6
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Inhibitory effects of gossypol on the female reproductive system have been recently reported. This study investigated a possible site of gossypol action on progesterone synthesis. Bovine luteal cells were cultured with hCG and forskolin in the presence or absence of gossypol. At 10 μg/ml, gossypol significantly inhibited hCG- and forskolin-stimulated progesterone secretion and intracellular cAMP formation; at 20 μg/ml, gossypol completely abolished the stimulative effect of hCG and forskolin. The results suggest that adenylate cyclase may be a site of gossypol action on steroidogenesis of bovine luteal cells. © 1990.
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页码：407 / 414
页数：8
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