EFFECT OF ANTIPSYCHOTIC-DRUGS ON THE MOLECULAR ACTION OF CHOLERA-TOXIN IN RABBIT INTESTINAL EPITHELIAL-CELLS

被引：1
|
作者：
LONGBOTTOM, D [1 ]
VANHEYNINGEN, S [1 ]
机构：
[1] UNIV EDINBURGH, DEPT BIOCHEM, EDINBURGH EH8 9XD, SCOTLAND
来源：
FEBS LETTERS | 1990年 / 272卷 / 1-2期
关键词：
Adenylate cyclase; ADP-ribosylation; Antipsychotic drug; Cholera toxin;
D O I：
10.1016/0014-5793(90)80444-N
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Antipsychotic drugs of known antidiarrhoeal and anticalmodulin activity inhibited the cholera-toxin-catalysed ADP-ribosylation of proteins of Mr, 37000,40000 and 45000 (thought to be regulatory components of the adenylate cyclase complex) that was previously shown to occur in plasma membranes from rabbit intestinal epithelial cells [(1989) Biochim. Biophys. Acta 1014, 289-297]. There was no obvious correlation between the different activities of the drugs. The drugs also inhibited adenylate cyclase activity, but in this case the inhibition correlated well with the known IC50 values of the drugs for anticalmodulin activity and with their antidiarrhoeal activities. © 1990.
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页码：41 / 44
页数：4
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