VIMENTIN AND DESMIN EXPRESSION IN DEGENERATING AND REGENERATING DYSTROPHIC MURINE MUSCLES

被引：0
|
作者：
BROCKS, L [1 ]
JAP, PHK [1 ]
RAMAEKERS, FCS [1 ]
STADHOUDERS, AM [1 ]
机构：
[1] STATE UNIV LIMBURG,DEPT MOLEC CELL BIOL,6200 MD MAASTRICHT,NETHERLANDS
来源：
VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY | 1991年 / 61卷 / 02期
关键词：
VIMENTIN; DESMIN; CYTOSKELETON; DYSTROPHY; MOUSE; MUSCLE;
D O I：
暂无
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The distribution of the intermediate filament proteins (IFP) desmin and vimentin was studied in gastrocnemius, plantaris and soleus muscles of the dystrophic mouse strain ReJ 129 during postnatal development. Special attention was paid to the overall morphological changes in the distribution of these cytoskeletal constituents in degenerating and regenerating muscle fibres. In contrast to their normal counterparts, the dystrophic mice (ReJ 129 dy/dy) appeared to develop four types of distinct muscle fibres with immunohistochemically detectable aberrant IFP patterns. The distribution of desmin IFP differed in the dystrophic muscle fibres as compared to the normal fibres in that juxtanuclear aggregates of IFP were frequently seen. In contrast to the recent literature we conclude that these cells are regenerated myofibres exhibiting defective nuclear migration.
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页码：89 / 96
页数：8
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