THE EXPRESSION OF PHOSPHOLIPASE-A2 AND LIPOCORTINS (ANNEXIN)-I, (ANNEXIN)-II AND (ANNEXIN)-V IN HUMAN FETAL MEMBRANES AND PLACENTA IN ASSOCIATION WITH LABOR

We have studied the expression of the cellular, type two phospholipase A2 and lipocortins (annexins) I, II and V in human amnion, chorion-decidua and placenta using northern analysis. We found no difference in the expression of phospholipase A2 or lipocortin V in tissues obtained before or after labour. Lipocortin I expression was found to decrease in amnion and placenta but increase in chorion decidua with the onset of labour, while expression of lipocortin II increased only in amnion. These results support the hypothesis that the increased phospholipase A2 activity in the fetal membranes and placenta which is associated with labour is not due to increased phospholipase A2 gene expression, but that post translational control of phospholipase A2 activity may be mediated through changes in lipocortin I expression.