STIMULATORY EFFECTS OF BOMBESIN ON PLASMA TRYPSIN RELEASE AND EXOCRINE PANCREATIC-SECRETION IN DOGS

被引：2
|
作者：
KIRIYAMA, S
HAYAKAWA, T
KONDO, T
SHIBATA, T
KITAGAWA, M
SAKAI, Y
SOBAJIMA, H
IKEI, N
KODAIRA, T
HAMAOKA, T
机构：
[1] NAGOYA UNIV,SCH MED,DEPT INTERNAL MED 2,TSURUMA CHO 65,SHOWA KU,NAGOYA,AICHI 466,JAPAN
[2] OTSUKA PHARMACEUT CO LTD,TOKUSHIMA,JAPAN
[3] OSAKA UNIV,SCH MED,INST CANC RES,OSAKA,JAPAN
来源：
DIGESTION | 1990年 / 46卷 / 02期
关键词：
Atropine; Bombesin; Exocrine pancreatic secretion; Plasma trypsin;
D O I：
10.1159/000200336
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
We examined the effect of bombesin on plasma trypsin release and exocrine pancreatic secretion in dogs. Bombesin significantly increased plasma immunoreactive trypsin (IRT). Atropine significantly inhibited the response of plasma IRT to bombesin. Pancreatic trypsin secretion was also increased by bombesin, as well as bicarbonate and protein outputs. Atropine failed to inhibit pancreatic trypsin secretion. In conclusion, bombesin has a stimulatory effect on plasma trypsin release mediated by a cholinergic mechanism and different from pancreatic secretion.
引用
收藏
页码：81 / 88
页数：8
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