CARBONIC-ANHYDRASE INHIBITORS FROM THE PERICARPS OF PUNICA-GRANATUM L

Seven highly active inhibitors against carbonic anhydrase (CA, EC 4.2.1.1), punicalin (2). punicalagin (3), granatin B(5), gallagyldilactone (7), casuarinin (8), pedunculagin (9) and tellimagrandin I (10), and four weakly active inhibitors, gallic acid (1), granatin A(4), corilagin (6) and ellagic acid(11), were isolated from the pericarps of Punica granatum L. (Punicaceae). They are ellagitannins. The type of inhibition by 3 and - using p-nitrophenyl acetate as a substrate is noncompetitive. The structure-activity relationship of inhibitory effects on CA is discussed.