DRUG RELEASE FROM SPRAY-DRIED AND SPRAY-EMBEDDED MICROPARTICLES OF DILTIAZEM HYDROCHLORIDE

被引：0

作者：

FORNI, F ^{[1
]}

COPPI, G ^{[1
]}

VANDELLI, MA ^{[1
]}

CAMERONI, R ^{[1
]}

机构：

[1] UNIV MODENA, DEPT PHARMACEUT SCI, VIA G CAMPI 183, I-41100 MODENA, ITALY

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1991年 / 39卷 / 08期

关键词：

DILTIAZEM HYDROCHLORIDE; ETHYLCELLULOSE; MICROPARTICLES; SPRAY-DRIED MICROPARTICLES; MICROCAPSULES; SPRAY-EMBEDDED MICROPARTICLES; MICROSPHERES; DRUG PHYSICAL STATE; DRUG RELEASE;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Spray-dried and spray-embedded ethylcellulose microparticles were prepared using a spray-drying technique. The structure of the microparticles (microcapsules or microspheres) changed according to whether the drug (diltiazem hydrochloride) was dispersed or dissolved in the ethylcellulose solution to be spray-dried. The drug release rate from the microparticles was not affected by the physical state of the drug (amorphous or crystalline state), but by the microparticle structure.

引用

页码：2091 / 2095

页数：5

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