BIOLOGICALLY-ACTIVE TRITERPENE SAPONINS FROM BUPLEURUM-FRUTICOSUM

被引：40
|
作者：
GUINEA, MC
PARELLADA, J
LACAILLEDUBOIS, MA
WAGNER, H
机构：
[1] UNIV BOURGOGNE, FAC PHARM, PHARMACOGNOSIE LAB, F-21033 DIJON, FRANCE
[2] UNIV MUNICH, INST PHARMACEUT BIOL, D-80333 MUNICH, GERMANY
来源：
PLANTA MEDICA | 1994年 / 60卷 / 02期
关键词：
BUPLEURUM FRUTICOSUM; APIACEAE; SAIKOSAPONIN; MALONYLSAIKOSAPONIN; ANTIHEPATOTOXIC ACTIVITY; GRANULOCYTE PHAGOCYTOSIS STIMULATION; LEUCINE AMINOPEPTIDASE INHIBITION;
D O I：
10.1055/s-2006-959442
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Extracts of the root of B. fruticosum L. showed in a biological screening hemolytical activity, hepatoprotective and phagocytosis stimulating effects, and a specific inhibitory activity of leucine aminopeptidase. Further monitoring of the fraction with antihepatotoxic activity led to the isolation of an hepatoprotective saikosaponin identified as buddlejasaponin IV and the new malonylbuddlejasaponin IV, determined as saikogenin F-3-O-[6-O-malonyl-beta-D-glucopyranosyl(1-->2)-beta-D-glucopyranosyl(1-->3)]-beta-D-fucopyranoside. The structures were elucidated on the basis of the chemical and spectroscopic data.
引用
收藏
页码：163 / 167
页数：5
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