SYNTHESIS OF SOME 3',5'-DIDEOXY-5'-C-PHOSPHONOMETHYL NUCLEOSIDES

被引：6

作者：

IOANNIDIS, P

CLASSON, B

SAMUELSSON, B

KVARNSTROM, I

机构：

[1] UNIV STOCKHOLM,ARRHENIUS LAB,DEPT ORGAN CHEM,S-10691 STOCKHOLM,SWEDEN

[2] LINKOPING UNIV,DEPT CHEM,S-58183 LINKOPING,SWEDEN

[3] AB HASSLE,DEPT ORGAN CHEM,S-43183 MOLNDAL,SWEDEN

来源：

ACTA CHEMICA SCANDINAVICA | 1991年 / 45卷 / 07期

关键词：

D O I：

10.3891/acta.chem.scand.45-0746

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ammonium [1-(3',5',6'-trideoxy-beta-D-erythro-hexofuranosyl)thymine]-6'-phosphonate (1), ammonium 3',5'-dideoxycytidine-5'-C-methylphosphonate (2) and 3',5'-dideoxyadenosine-5'-C-methyl phosphonic acid (3) have been synthesized and tested for anti-HIV activity. The key steps involved an Arbuzov reaction between triethyl phosphite and 3,5,6-trideoxy-6-iodo-1,2-O-isopropylidene-alpha-D-erythro-hexofuranose (7), followed by condensation with the appropriate nucleoside bases. The substances 1, 2 and 3 have been tested in vitro against HIV.

引用

页码：746 / 750

页数：5

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