PREDICTION OF HUMAN PHARMACOKINETICS OF PANIPENEM, A NEW CARBAPENEM ANTIBIOTIC, FROM ANIMAL DATA

被引：0

作者：

NAKASHIMA, M ^{[1
]}

KURIHARA, A ^{[1
]}

HISAOKA, M ^{[1
]}

机构：

[1] SANKYO CO LTD, PROD DEV LABS, SHINAGAWA KU, TOKYO 140, JAPAN

来源：

DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH | 1992年 / 18卷 / 09期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The prediction of human pharmacokinetics of Panipenem (PAPM), which is a new carbapenem antibiotic, was investigated using animal data. The plasma concentration-time curve after intravenous administration of PAPM in each animal showed biexponential elimination. There were good allometric correlations between pharmacokinetic parameters (CLtotal and Vd,ss) calculated from the plasma concentration in animal species and body weight of experimental animals. Predicted human pharmacokinetic parameters calculated by these allometric equations agreed with the values observed in humans.

引用

页码：371 / 375

页数：5

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