The origins of dengue outbreaks in northern Queensland, Australia, 1990-2017

Dengue is one of the world's major infectious mosquito-borne diseases and although not endemic in Australia, is a significant public health concern. Queensland is vulnerable to outbreaks of dengue viruses (DENVs) and indeed, due to endemic populations of the mosquito vector Aedes aeypti, has been the only state since the 1950s to record local transmission. Determining DENV outbreak origins, and monitoring strain movement and diversity greatly assists outbreak management. It also confirms epidemiological links and potentially identifies incursions of rare or highly pathogenic viruses. There have been 73 DENV outbreaks recorded in northern Queensland within the past three decades and it has been the role of Public Health Virology, Department of Health, Queensland Government, to provide DENV genotyping and characterisation to facilitate this essential surveillance. This review summarises the likely origins of the recent northern Queensland outbreaks and describes the complex dynamics of DENV genotypic diversity that have characterised local transmission events.