DECREASED INVITRO SUSCEPTIBILITY TO ZIDOVUDINE OF HIV ISOLATES OBTAINED FROM PATIENTS WITH AIDS

被引：115
|
作者：
LAND, S
TRELOAR, G
MCPHEE, D
BIRCH, C
DOHERTY, R
COOPER, D
GUST, I
机构：
[1] FAIRFIELD HOSP,MACFARLANE BURNET CTR MED RES,NATL HLTH & MRC SPECIAL UNIT AIDS VIROL,FAIRFIELD,VIC 3078,AUSTRALIA
[2] NATL HLTH & MRC SPECIAL UNIT AIDS EPIDEMIOL & CLIN RES,SYDNEY,AUSTRALIA
来源：
JOURNAL OF INFECTIOUS DISEASES | 1990年 / 161卷 / 02期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1093/infdis/161.2.326
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This study tested isolates of human immunodeficiency virus, obtained beforeand after zidovudine therapy from 10 patients, for susceptibility to the drug in vitro. The isolates collected after therapy were less susceptible to zidovudine as assessed by replication in MT-2 cells and production of reverse transcriptase activity by infected mononuclear leucocytes in the presence of the drug. Furthermore, pretherapy isolates were sensitive to a range of zidovudine concentrations when 100% inhibition was used as the end point. The loss of zidovudine susceptibility did not correlate with any clinical or virologic consequences in this small group of patients. © 1990 by The University of Chicago. All rights reserved.
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页码：326 / 329
页数：4
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