THE SYNTHESIS OF A WATER-SOLUBLE COMPLEMENT ACTIVATING POLYACRYLIC-ACID IGG POLYMER

被引：2

作者：

SCHMER, G ^{[1
]}

HENDERSON, RA ^{[1
]}

MULLER, W ^{[1
]}

机构：

[1] UNIV BASEL,FELIX PLATTER SPITALS,RHEUMATOL KLIN,CH-4012 BASEL,SWITZERLAND

来源：

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | 1994年 / 6卷 / 01期

关键词：

POLYACRYLIC ACID IGG POLYMER; COMPLEMENT ACTIVATION; IMMUNE COMPLEX;

D O I：

10.1163/156856295X00760

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Polyacrylic acid-IgG polymer (PAA-IgG) activates the classical and alternative pathway of complement as shown by specific C1q-(IgG-PAA) interaction and the generation of C4d, Bb, C3b, C3a and C5a. This water soluble and stable PAA-IgG polymer represents a model substance for the study of humoral and cellular inflammatory mechanisms, mediated by the complement system.

引用

页码：67 / 78

页数：12

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