THE SYNTHESIS OF A WATER-SOLUBLE COMPLEMENT ACTIVATING POLYACRYLIC-ACID IGG POLYMER

被引：2
|
作者：
SCHMER, G [1 ]
HENDERSON, RA [1 ]
MULLER, W [1 ]
机构：
[1] UNIV BASEL,FELIX PLATTER SPITALS,RHEUMATOL KLIN,CH-4012 BASEL,SWITZERLAND
来源：
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | 1994年 / 6卷 / 01期
关键词：
POLYACRYLIC ACID IGG POLYMER; COMPLEMENT ACTIVATION; IMMUNE COMPLEX;
D O I：
10.1163/156856295X00760
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Polyacrylic acid-IgG polymer (PAA-IgG) activates the classical and alternative pathway of complement as shown by specific C1q-(IgG-PAA) interaction and the generation of C4d, Bb, C3b, C3a and C5a. This water soluble and stable PAA-IgG polymer represents a model substance for the study of humoral and cellular inflammatory mechanisms, mediated by the complement system.
引用
收藏
页码：67 / 78
页数：12
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