Clinicopathologic Features and Early Surgical Outcome of Astrocytomas in Eldoret, Kenya

被引:3
|
作者
Mwita, Clifford C. [1 ,5 ]
Koech, Florentius [1 ]
Sisenda, Titus [1 ]
Patel, Kirtika [2 ]
Macharia, Benson [3 ]
Rahangdale, Devendra [4 ]
机构
[1] Moi Univ, Sch Med, Dept Surg & Anesthesiol, POB 4606-30100, Eldoret, Kenya
[2] Moi Univ, Sch Med, Dept Immunol, Eldoret, Kenya
[3] Moi Univ, Sch Med, Dept Pathol & Forens Med, Eldoret, Kenya
[4] Mediheal Hosp, Dept Radiol, Eldoret, Kenya
[5] Afya Res Africa, Nairobi, Kenya
关键词
Astrocytoma; brain neoplasms; glioblastoma; Ki67;
D O I
10.4103/jnrp.jnrp_562_17
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Astrocytomas are primary central nervous system tumors arising from astrocytes and accounting for up to 37.8% of all brain tumors seen in hospital-based studies from Africa. Despite being common, their patterns and short-term outcomes remain poorly studied in Kenya. Materials and Methods: A prospective, descriptive study involving consecutive patients with a histological diagnosis of astrocytoma seen in three hospitals located in Eldoret, Kenya. Clinicopathologic characteristics and outcomes were recorded and patients followed up for 12 weeks. Results: Thirty-one patients were recruited over a 1-year period. Majority of them were female (51.6%). Headache (83.9%) and focal neurological deficits (64.5%) were the most common presenting features. Among patients with high-grade tumors, mean duration of illness was 106.03 +/- 162.16 days, median functional status was Karnofsky performance status (KPS) score 50, mean tumor size was 110.22 +/- 46.16 cm(3), and median magnetic resonance imaging (MRI) score was 17. Among patients with low-grade astrocytomas, mean duration of illness was 213.03 +/- 344.93 days, median functional status was KPS score 40, mean tumor size was 53.49 +/- 54.96 cm(3) and median MRI score was 9. Glioblastoma multiforme (GBM) (71%) and diffuse astrocytoma (22.6%) were the predominant histological subtypes. The median Ki-67 proliferative index was 6% for pilocytic astrocytoma, 1.6% for diffuse astrocytoma, and 60% for GBM. Systemic and regional surgical complications occurred in 6.5% and 38.7% of patients, respectively. In-hospital mortality was 19.4% and increased to 25.8% at 12 weeks. The KPS score at discharge was 50 and improved to 60 at 12 weeks. Only 9.7% of patients had acceptable functional status at 12 weeks follow-up. Conclusions: In this locality, headache, focal neurological deficits, and reduced functional status are the most common presenting features of astrocytomas while GBM is the most common histological subtype. Tumors are highly proliferative and in the short-term, both surgical and functional outcome are suboptimal.
引用
收藏
页码:363 / 369
页数:7
相关论文
共 50 条
  • [21] Idiopathic retroperitoneal fibrosis: clinicopathologic features and outcome analysis
    Ralph Yachoui
    Rahul Sehgal
    Brett Carmichael
    Clinical Rheumatology, 2016, 35 : 401 - 407
  • [22] Recurrence of thymoma: Analysis of clinicopathologic features, treatment, and outcome
    Ruffini, E
    Mancuso, M
    Oliaro, A
    Casadio, C
    Cavallo, A
    Cianci, R
    Filosso, PL
    Molinatti, M
    Porrello, C
    Cappello, N
    Maggi, G
    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 1997, 113 (01): : 55 - 63
  • [23] Clinicopathologic Features and Surgical Outcomes of Neuroendocrine Carcinoma of the Gallbladder
    Tanioka, Nobuhisa
    Okabayashi, Takehiro
    Iwata, Jun
    Sui, Kenta
    Morita, Sojiro
    Matsumoto, Takatsugu
    Shimada, Yasuhiro
    SURGICAL TECHNOLOGY INTERNATIONAL-INTERNATIONAL DEVELOPMENTS IN SURGERY AND SURGICAL RESEARCH, 2019, 34
  • [24] INTRAVENTRICULAR PILOCYTIC ASTROCYTOMAS: RADIOLOGY, SURGICAL MANAGEMENT AND OUTCOME IN A SERIES OF 8 PATIENTS
    Pasricha, R.
    Dash, C.
    Singh, P. K.
    Borkar, S. A.
    Kumar, A.
    Kaur, K.
    Suri, V.
    Sharma, B. S.
    Mahapatra, A. K.
    NEURO-ONCOLOGY, 2017, 19 : 90 - 90
  • [25] Clinicopathologic characteristics and surgical outcome of synthetic fiber conjunctival granuloma
    Zhang Chen
    Tianyang Wang
    Qintuo Pan
    Zhaoliang Zhang
    Zongduan Zhang
    BMC Ophthalmology, 20
  • [26] Clinicopathologic features and surgical management of dissecting glaucoma filtering blebs
    Ulrich, GG
    Proia, AD
    Shields, MB
    OPHTHALMIC SURGERY AND LASERS, 1997, 28 (02): : 151 - 155
  • [27] Intrabiliary Growth of Liver Metastases Clinicopathologic Features, Prevalence, and Outcome
    Estrella, Jeannelyn S.
    Othman, Mohammad L.
    Taggart, Melissa W.
    Hamilton, Stanley R.
    Curley, Steven A.
    Rashid, Asif
    Abraham, Susan C.
    AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2013, 37 (10) : 1571 - 1579
  • [28] EARLY PATHOLOGIC FEATURES OF HEREDITARY NEPHRITIS - A CLINICOPATHOLOGIC CORRELATION
    ONEILL, WM
    MENNEMEYER, RP
    BLOOMER, HA
    ATKIN, CL
    PATHOLOGY RESEARCH AND PRACTICE, 1980, 168 (1-3) : 146 - 162
  • [29] Clinicopathologic characteristics and surgical outcome of synthetic fiber conjunctival granuloma
    Chen, Zhang
    Wang, Tianyang
    Pan, Qintuo
    Zhang, Zhaoliang
    Zhang, Zongduan
    BMC OPHTHALMOLOGY, 2020, 20 (01)
  • [30] INTRAVENTRICULAR PILOCYTIC ASTROCYTOMAS: RADIOLOGY, SURGICAL MANAGEMENT AND OUTCOME IN A SERIES OF 8 PATIENTS
    Pasricha, Ribhav
    Dash, Chinmaya
    Singh, Pankaj
    Borkar, Sachin
    Sharma, Bhawani S.
    NEURO-ONCOLOGY, 2018, 20 : 4 - 4