THE B-CELL ANTIGEN RECEPTOR OF THE 5 IMMUNOGLOBULIN CLASSES

被引：270
|
作者：
VENKITARAMAN, AR [1 ]
WILLIAMS, GT [1 ]
DARIAVACH, P [1 ]
NEUBERGER, MS [1 ]
机构：
[1] UNIV MONTPELLIER 2,IMMUNOGENET MOLEC LAB,F-34060 MONTPELLIER,FRANCE
来源：
NATURE | 1991年 / 352卷 / 6338期
关键词：
D O I：
10.1038/352777a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Several proteins associate with surface IgM to form the antigen receptor. We show that just two, the alpha and beta associated chains, are sufficient to reconstitute an IgM surface receptor in fibroblasts. Contrary to expectation, a common alpha-chain associates with all five immunoglobulin classes. We propose that B-cell antigen receptors consist of a common alpha/beta heterodimer associated with each immunoglobulin class. But the classes differ both in the glycosylation of their associated alpha-chain and in their dependence on alpha/beta for surface transport.
引用
收藏
页码：777 / 781
页数：5
相关论文
共 50 条
  • [21] IS EXPRESSION OF THE B-CELL ANTIGEN RECEPTOR REPERTOIRE CHAOTIC
    COLECLOUGH, C
    LANGMAN
    COHN
    WU
    RAMSDEN
    COLECLOUGH
    RESEARCH IN IMMUNOLOGY, 1992, 143 (08): : 824 - 839
  • [22] B-CELL TOLERANCE IS MEDIATED BY ANTIGEN RECEPTOR DESENSITIZATION
    COOKE, MP
    ZENG, K
    HEATH, A
    LINSLEY, P
    HOWARD, M
    GOODNOW, CC
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1993, : 248 - 248
  • [23] To make antibodies or not: signaling by the B-cell antigen receptor
    Gold, MR
    TRENDS IN PHARMACOLOGICAL SCIENCES, 2002, 23 (07) : 316 - 324
  • [24] Immunoglobulin class switching appears to be regulated by B-cell antigen receptor-specific T-cell action
    Lange, Hans
    Hecht, Oliver
    Zemlin, Michael
    Trad, Ahmad
    Tanasa, Radu I.
    Schroeder, Harry W., Jr.
    Lemke, Hilmar
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2012, 42 (04) : 1016 - 1029
  • [25] ANTI-IMMUNOGLOBULIN AUGMENTS THE B-CELL ANTIGEN-PRESENTATION FUNCTION INDEPENDENTLY OF INTERNALIZATION OF RECEPTOR-ANTIGEN COMPLEX
    CASTEN, LA
    LAKEY, EK
    JELACHICH, ML
    MARGOLIASH, E
    PIERCE, SK
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (17) : 5890 - 5894
  • [26] PEPTIDE LIGANDS FOR THE IMMUNOGLOBULIN RECEPTOR (IG) OF A B-CELL LYMPHOMA
    RENSCHLER, MF
    BHATT, R
    DOWER, W
    LEVY, R
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1993, : 233 - 233
  • [27] B-CELL REPERTOIRE DIVERSIFICATION PRECEDES IMMUNOGLOBULIN RECEPTOR EXPRESSION
    RILEY, RL
    WYLIE, DE
    KLINMAN, NR
    JOURNAL OF EXPERIMENTAL MEDICINE, 1983, 158 (05): : 1733 - 1738
  • [28] EXPRESSION OF A B-CELL MEMBRANE ANTIGEN DISTINGUISHES B-CELL ACTIVATION THROUGH IA VS SURFACE-IMMUNOGLOBULIN
    CROW, MK
    JOVER, JA
    FRIEDMAN, SM
    CLINICAL RESEARCH, 1986, 34 (02): : A493 - A493
  • [29] Identification of Antigen-Specific B-Cell Receptor Sequences from the Total B-Cell Repertoire
    Galson, Jacob D.
    Kelly, Dominic F.
    Truck, Johannes
    CRITICAL REVIEWS IN IMMUNOLOGY, 2015, 35 (06) : 463 - 478
  • [30] Antigen-Independent, Autonomous B-Cell Receptor Signaling in Diffuse Large B-Cell Lymphoma
    Eken, Janneke A.
    Koning, Marvyn T.
    Yanez, Julieta H. Sepulveda
    van Bergen, Cornelis A. M.
    Quinten, Edwin
    Kupcova, Kristyna
    Havranek, Ondrej
    De Groen, Ruben A. L.
    Vermaat, Joost S. P.
    de Jong, Daphne
    Kluin, Philip
    Cleven, Arjen
    Jumaa, Hassan
    Veelken, Hendrik
    BLOOD, 2022, 140 : 6444 - 6445
12345