THE B-CELL ANTIGEN RECEPTOR OF THE 5 IMMUNOGLOBULIN CLASSES

被引：270
|
作者：
VENKITARAMAN, AR [1 ]
WILLIAMS, GT [1 ]
DARIAVACH, P [1 ]
NEUBERGER, MS [1 ]
机构：
[1] UNIV MONTPELLIER 2,IMMUNOGENET MOLEC LAB,F-34060 MONTPELLIER,FRANCE
来源：
NATURE | 1991年 / 352卷 / 6338期
关键词：
D O I：
10.1038/352777a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Several proteins associate with surface IgM to form the antigen receptor. We show that just two, the alpha and beta associated chains, are sufficient to reconstitute an IgM surface receptor in fibroblasts. Contrary to expectation, a common alpha-chain associates with all five immunoglobulin classes. We propose that B-cell antigen receptors consist of a common alpha/beta heterodimer associated with each immunoglobulin class. But the classes differ both in the glycosylation of their associated alpha-chain and in their dependence on alpha/beta for surface transport.
引用
收藏
页码：777 / 781
页数：5
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