STRUCTURAL STUDY OF 5-METHOXYFURO[3,2-E]IMIDAZO[1,2-C]PYRIMIDINE

被引：1

作者：

QUIJANO, ML

NOGUERAS, M

SANCHEZ, A

MELGAREJO, M

LOPEZ, R

JIMENO, ML

LOW, JN

HOWIE, RA

FERGUSON, G

机构：

[1] FAC FARM GRANADA,DEPT QUIM ORGAN,E-18071 GRANADA,SPAIN

[2] CTR NACL QUIM ORGAN,E-28006 MADRID,SPAIN

[3] UNIV DUNDEE,DEPT APPL PHYS ELECTR & MFG ENGN,DUNDEE DD1 4HN,SCOTLAND

[4] UNIV ABERDEEN,DEPT CHEM,ABERDEEN AB9 2UE,SCOTLAND

[5] UNIV GUELPH,DEPT CHEM,GUELPH,ON N1G 2W1,CANADA

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1994年 / 31卷 / 06期

关键词：

D O I：

10.1002/jhet.5570310651

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The nmr and X-ray diffraction data of the novel ring system furo[3,2-e]imidazo[1,2-c]pyrimidine are reported in this paper. The crystal and molecular structure of this compound (C9H7N3O2.1/2H2O) has been solved at room temperature. Crystals are monoclinic in a space group of P2/n with cell constants a = 9.982(8), b = 13.526(9) and c = 13.981(9) angstrom, beta = 107.44(5)-degrees, V = 1800.9 angstrom3, Z = 8, D(x) = 1.462 Mg.m-3. The structure was solved by full matrix least square refinement giving a final R = 0.054 (Rw = 0.069) for 1263 reflections (I>3.0sigma(I)). The compound is essentially planar, existing in two slightly structural different forms, A and B. These are held in pairs with symmetry related molecules by hydrogen bonds formed with two water molecules. Then the dimeric units are stacked parallel to the c axis to form the tridimensional packing.

引用

页码：1583 / 1588

页数：6

共 50 条

[41] Design, synthesis, and cytotoxic activity of novel 2H-imidazo[1,2-c] pyrazolo[3,4-e]pyrimidine derivatives
Zheng, You-Guang
Pei, Xin
Xia, De-Xin
Wang, Yuan-Bo
Jiang, Ping
An, Lin
Huang, Tong-Hui
Xue, Yun-Sheng
BIOORGANIC CHEMISTRY, 2021, 109
[42] IMIDAZO[1,2-C]PYRIMIDINE NUCLEOSIDES - SYNTHESIS OF N-BRIDGEHEAD IMP AND GMP ANALOGS
BARTHOLOMEW, DG
ROBINS, RK
REVANKAR, GR
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1975, 170 (AUG24): : 55 - 55
[43] Novel imidazo[1,2-c]pyrimidine base-modified nucleosides:: synthesis and antiviral evaluation
Kifli, N
De Clercq, E
Balzarini, J
Simons, C
BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (15) : 4245 - 4252
[44] Imidazo[1,2-c]pyrimidine Azo-Dyes: Synthesis, Characterization, DFT, and Fluorescence Properties
Mohammed, S. M.
Shehta, W.
Moustafa, A. H.
Salem, A. M.
Masry, A. A.
El-Sayed, H. A.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2024, 94 (11) : 3003 - 3014
[45] SYNTHESIS OF IMIDAZO [1,2-C]PYRIMIDINE DERIVATIVES FROM 4-AMINOPYRIMIDINES, METHYLKETONES AND HALOGENS
ROGULCHENKO, GK
MAZUR, IA
KOCHERGIN, PM
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1975, (01): : 93 - 94
[46] Synthesis and biological evaluation of benzo[4,5]imidazo[1,2-c] pyrimidine and benzo[4,5]imidazo[1,2-a]pyrazine derivatives as anaplastic lymphoma kinase inhibitors
Tardy, Sebastien
Orsato, Alexandre
Mologni, Luca
Bisson, William H.
Donadoni, Carla
Gambacorti-Passerini, Carlo
Scapozza, Leonardo
Gueyrard, David
Goekjian, Peter G.
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 22 (04) : 1303 - 1312
[47] Synthesis of the novel pyrimido[1,6-a]pyrimidine and imidazo[1,2-c]pyrimidine derivatives based on heterocyclic ketene aminals
Alizadeh, Abdolali
Mokhtari, Javad
Ahmadi, Mehdi
TETRAHEDRON, 2012, 68 (01) : 319 - 322
[48] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF TETRAHYDROPYRIDO[2',3'4,5]IMIDAZO[1,2-C]PYRIMIDINE-6,8-DIONES
SRAGA, J
GUERRY, P
KOMPIS, I
HELVETICA CHIMICA ACTA, 1994, 77 (04) : 1057 - 1064
[49] Sc(OTf)3 promoted multicomponent synthesis of fluorescent imidazo[1,2-c]pyrazolo[3,4-d]pyrimidine
Agrebi, Asma
Allouche, Fatma
Chabchoub, Fakher
El-Kaim, Laurent
Alves, Sergio
Baleizao, Carlos
Farinha, Jose Paulo
TETRAHEDRON LETTERS, 2013, 54 (35) : 4781 - 4784
[50] Synthesis of imidazo[4,5-e]benzo[1,2-c;3,4-c´]difuroxanes
V. L. Korolev
V. V. Toporov
N. L. Merkulova
V. M. Danilenko
V. P. Ivshin
T. S. Pivina
Russian Chemical Bulletin, 2017, 66 : 1250 - 1255

← 1 2 3 4 5 →