Are statins beneficial for chronic heart failure?

被引：1

作者：

Rain, Carmen ^{[1
,5
]}

Rada, Gabriel ^{[1
,2
,3
,4
,5
]}

机构：

[1] Pontificia Univ Catolica Chile, Fac Med, Programa Salud Basada Evidencia, Santiago, Chile

[2] Pontificia Univ Catolica Chile, Fac Med, Dept Med Interna, Santiago, Chile

[3] GRADE Working Grp, Mexico City, DF, Mexico

[4] Cochrane Collaborat, Mexico City, DF, Mexico

[5] Proyecto Epistemonikos, Mexico City, DF, Mexico

来源：

MEDWAVE | 2015年 / 15卷 / 04期

关键词：

D O I：

10.5867/medwave.2015.04.6140

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is controversy about the role of statins in chronic heart failure. Even though it is clear they decrease inflammatory markers and probably improve some echocardiographic parameters, it is not clear if they impact clinically important outcomes. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified six systematic reviews including 21 randomized trials. We combined the evidence using meta- analysis and generated a summary of findings table following the GRADE approach. We concluded statins in chronic heart failure do not decrease mortality, and might lead to little or no decrease in hospitalizations for heart failure or other clinical outcomes.

引用

页数：8

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