Are statins beneficial for chronic heart failure?

被引：1

作者：

Rain, Carmen ^{[1
,5
]}

Rada, Gabriel ^{[1
,2
,3
,4
,5
]}

机构：

[1] Pontificia Univ Catolica Chile, Fac Med, Programa Salud Basada Evidencia, Santiago, Chile

[2] Pontificia Univ Catolica Chile, Fac Med, Dept Med Interna, Santiago, Chile

[3] GRADE Working Grp, Mexico City, DF, Mexico

[4] Cochrane Collaborat, Mexico City, DF, Mexico

[5] Proyecto Epistemonikos, Mexico City, DF, Mexico

来源：

MEDWAVE | 2015年 / 15卷 / 04期

关键词：

D O I：

10.5867/medwave.2015.04.6140

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is controversy about the role of statins in chronic heart failure. Even though it is clear they decrease inflammatory markers and probably improve some echocardiographic parameters, it is not clear if they impact clinically important outcomes. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified six systematic reviews including 21 randomized trials. We combined the evidence using meta- analysis and generated a summary of findings table following the GRADE approach. We concluded statins in chronic heart failure do not decrease mortality, and might lead to little or no decrease in hospitalizations for heart failure or other clinical outcomes.

引用

页数：8

共 50 条

[1] The role of statins in chronic heart failure
Szygula-Jurkiewicz, Bozena
Szczurek, Wioletta
Krol, Bogumila
Zembala, Marian
[J]. KARDIOCHIRURGIA I TORAKOCHIRURGIA POLSKA, 2014, 11 (03): : 301 - 305
[2] The role of statins in chronic heart failure
Sadek, Mouhannad M.
Haddad, Taleen
Haddad, Haissam
[J]. CURRENT OPINION IN CARDIOLOGY, 2009, 24 (02) : 167 - 171
[3] Statins Beneficial for Heart Failure With Preserved Ejection Fraction But Not Heart Failure With Reduced Ejection Fraction?
Ohte, Nobuyuki
Little, William C.
[J]. CIRCULATION JOURNAL, 2015, 79 (03) : 508 - 509
[4] Sympathoinhibitory effect of statins in chronic heart failure
Marc E. Gomes
Jacques W. M. Lenders
Louise Bellersen
Freek W. A. Verheugt
Paul Smits
Cees J. Tack
[J]. Clinical Autonomic Research, 2010, 20 : 73 - 78
[5] Statins and Autonomic Function in Chronic Heart Failure
Pim van der Harst
Adriaan A. Voors
Wiek H. van Gilst
Dirk J. van Veldhuisen
[J]. Cardiovascular Drugs and Therapy, 2005, 19 : 167 - 168
[6] Statins and autonomic function in chronic heart failure
van der Harst, P
Voors, AA
van Gilst, WH
van Veldhuisen, DJ
[J]. CARDIOVASCULAR DRUGS AND THERAPY, 2005, 19 (03) : 167 - 168
[7] Statins and oxidative stress in chronic heart failure
Costa, Sonia
Reina-Couto, Marta
Albino-Teixeira, Antonio
Sousa, Teresa
[J]. REVISTA PORTUGUESA DE CARDIOLOGIA, 2016, 35 (01) : 41 - 57
[8] Sympathoinhibitory effect of statins in chronic heart failure
Gomes, Marc E.
Lenders, Jacques W. M.
Bellersen, Louise
Verheugt, Freek W. A.
Smits, Paul
Tack, Cees J.
[J]. CLINICAL AUTONOMIC RESEARCH, 2010, 20 (02) : 73 - 78
[9] Beneficial effects of statins in patients with non-ischemic heart failure
Laufs, U
Wassmann, S
Schackmann, S
Heeschen, C
Böhm, M
Nickenig, G
[J]. ZEITSCHRIFT FUR KARDIOLOGIE, 2004, 93 (02): : 103 - 108
[10] Statins and the Role of Nitric Oxide in Chronic Heart Failure
Stephan von Haehling
Stefan D. Anker
Eberhard Bassenge
[J]. Heart Failure Reviews, 2003, 8 : 99 - 106

← 1 2 3 4 5 →