HETEROGENEITY AND STABILITY CHARACTERISTICS OF CANDID 1 ATTENUATED STRAIN OF JUNIN VIRUS

被引：0
|
作者：
CONTIGIANI, M
MEDEOT, S
DIAZ, G
机构：
来源：
ACTA VIROLOGICA | 1993年 / 37卷 / 01期
关键词：
JUNIN VIRUS; VACCINE STRAIN; CLONE SELECTION; POPULATION HETEROGENEITY AND STABILITY;
D O I：
暂无
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Fourteen clones of Candid 1 strain of Junin virus were studied in terms of their attenuation and stability for 9 days-old mice. The cluster analysis of the efficiency of lethal infection, namely the virulence (lethality) indicates (PFU/LD50) of the clones showed that the strain population is heterogeneous. It is constitued by subpopulations with lower and higher virulence as compared to the parent strain. Moreover, one or two passages through mice and Calomys musculinus, the main Junin virus reservoir of this strain produced changes of its virulence meanwhile the in vitro passages did not affect its attenuation level.
引用
收藏
页码：41 / 46
页数：6
相关论文
共 50 条
  • [41] Attenuated Phenotype and Immunogenic Characteristics of a Mutated Herpes Simplex Virus 1 Strain in the Rhesus Macaque
    Fan, Shengtao
    Xu, Xingli
    Liao, Yun
    Wang, Yongrong
    Wang, Jianbin
    Feng, Min
    Wang, Lichun
    Zhang, Ying
    He, Zhanlong
    Yang, Fengmei
    Fraser, Nigel W.
    Li, Qihan
    VIRUSES-BASEL, 2018, 10 (05):
  • [42] PATHOGENICITY OF AN ATTENUATED STRAIN (XJCL3) OF JUNIN VIRUS - MORPHOLOGICAL AND VIROLOGICAL STUDIES IN EXPERIMENTALLY INFECTED GUINEA-PIGS
    LAGUENS, RM
    AVILA, MM
    SAMOILOVICH, SR
    WEISSENBACHER, MC
    LAGUENS, RP
    INTERVIROLOGY, 1983, 20 (04) : 195 - 201
  • [43] CONGENITAL GUINEA-PIG INFECTION WITH ATTENUATED JUNIN VIRUS-STRAINS
    BOXACA, MC
    GOMEZ, MD
    MALUMBRES, E
    DEGUERRERO, LB
    INTERVIROLOGY, 1985, 23 (04) : 190 - 198
  • [44] PROTECTION INDUCED BY THE ATTENUATED XJO VARIANT OF JUNIN VIRUS IN GUINEA-PIGS
    BOXACA, MC
    DEGUERRERO, LB
    WEBER, EL
    MALUMBRES, E
    MEDICINA-BUENOS AIRES, 1981, 41 (01) : 25 - 34
  • [45] IMMUNIZATION AGAINST ARGENTINE HEMORRHAGIC FEVER WITH AN ATENNUATED STRAIN OF JUNIN VIRUS .I. STUDIES ON A MODIFIED STRAIN OF JUNIN VIRUS GUINEA PIG IMMUNIZATION
    DEGUERRE.LB
    WEISSENB.MC
    PARODI, AS
    MEDICINA, 1969, 29 (01): : 1 - &
  • [46] INFECTION OF PREGNANT GUINEA-PIGS WITH ATTENUATED JUNIN VIRUS-STRAINS
    GOMEZ, MDL
    BOXACA, MC
    INTERVIROLOGY, 1985, 23 (01) : 8 - 14
  • [47] SUCKLING GUINEA-PIG AS VIRULENCE MARKER FOR ATTENUATED STRAINS OF JUNIN VIRUS
    CONTIGIANI, MS
    SABATTINI, MS
    MEDICINA-BUENOS AIRES, 1984, 44 (04) : 376 - 382
  • [48] The Glycoprotein of the Live-Attenuated Junin Virus Vaccine Strain Induces Endoplasmic Reticulum Stress and Forms Aggregates prior to Degradation in the Lysosome
    Manning, John T.
    Yun, Nadya E.
    Seregin, Alexey, V
    Koma, Takaaki
    Sattler, Rachel
    Ezeomah, Chiomah
    Huang, Cheng
    de la Torre, Carlos
    Paessler, Slobodan
    JOURNAL OF VIROLOGY, 2020, 94 (08)
  • [49] STUDY OF AN ATTENUATED STRAIN OF MYXOMATOSIS VIRUS
    MARAL, R
    COMPTES RENDUS HEBDOMADAIRES DES SEANCES DE L ACADEMIE DES SCIENCES SERIE D, 1970, 271 (08): : 737 - &
  • [50] IgG subclasses in human immune response to wild and attenuated (vaccine) Junin virus infection
    Saavedra, MD
    Sottosanti, JM
    Riera, L
    Ambrosio, AM
    JOURNAL OF MEDICAL VIROLOGY, 2003, 69 (03) : 447 - 450
12345