HETEROGENEITY AND STABILITY CHARACTERISTICS OF CANDID 1 ATTENUATED STRAIN OF JUNIN VIRUS

被引：0
|
作者：
CONTIGIANI, M
MEDEOT, S
DIAZ, G
机构：
来源：
ACTA VIROLOGICA | 1993年 / 37卷 / 01期
关键词：
JUNIN VIRUS; VACCINE STRAIN; CLONE SELECTION; POPULATION HETEROGENEITY AND STABILITY;
D O I：
暂无
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Fourteen clones of Candid 1 strain of Junin virus were studied in terms of their attenuation and stability for 9 days-old mice. The cluster analysis of the efficiency of lethal infection, namely the virulence (lethality) indicates (PFU/LD50) of the clones showed that the strain population is heterogeneous. It is constitued by subpopulations with lower and higher virulence as compared to the parent strain. Moreover, one or two passages through mice and Calomys musculinus, the main Junin virus reservoir of this strain produced changes of its virulence meanwhile the in vitro passages did not affect its attenuation level.
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页码：41 / 46
页数：6
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