EFFECTS OF DIHYDROERGOTOXINE ON SOME DOPAMINE-RELATED BEHAVIORS IN RATS

被引：1
|
作者：
FLORIO, JC [1 ]
PALERMONETO, J [1 ]
机构：
[1] UNIV SAO PAULO, SCH VET MED, APPL PHARMACOL & TOXICIOL LAB, SAO PAULO, SP, BRAZIL
来源：
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1990年 / 21卷 / 04期
基金：
巴西圣保罗研究基金会;
关键词：
D O I：
10.1016/0306-3623(90)90690-N
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. The effects of dihydroergotoxine on open-field behavior, apomorphine-induced stereotipy and haloperidol-induced catalepsy were studied quantitatively in rats. 2. Dihydroergotoxine decreased the open-field behavior of rats, in a dose-dependent manner; this effect remained at least for 8 hr. 3. Dihydroergotoxine (10.0 mg/kg) caused a 1.40 leftward displacement of the dose-response curve constructed for apomorphine-induced stereotypy; the ED50 for apomorphine was reduced from 0.40 (±0.05) to 0.29 (±0.03). 4. Dihydroergotoxine (10.0 mg/kg) was unable to change haloperidol-induced catalepsy. 5. Results were discussed in the light of a possible interference of central noradrenergic systems with the expression of dopaminergic behaviors. © 1990.
引用
收藏
页码：411 / 415
页数：5
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