HLA-DQA1 ALLELE AND GENOTYPE FREQUENCIES IN A NORTHERN ITALIAN POPULATION

被引：8

作者：

DESTEFANO, F ^{[1
]}

CASARINO, L ^{[1
]}

MANNUCCI, A ^{[1
]}

DELFINO, L ^{[1
]}

CANALE, M ^{[1
]}

FERRARA, GB ^{[1
]}

机构：

[1] IST SCI STUDIO & CURA TUMORI,SERV IMMUNOGENET,I-16132 GENOA,ITALY

来源：

FORENSIC SCIENCE INTERNATIONAL | 1992年 / 55卷 / 01期

关键词：

HLA-DQA1; FREQUENCIES; POLYMERASE CHAIN REACTION (PCR);

D O I：

10.1016/0379-0738(92)90094-D

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

HLA-DQA1 typing of 227 randomly selected Northern Italian people by the use of polymerase chain reaction are reported. The combined use of commercial Amplitype HLA-DQalpha system and four sequence-specific oligonucleotide probes allows the definition of 8 alleles and 36 genotypes, arranged according to World Health Organisation nomenclature. Seven of these genotypes are not observed among the analyzed samples. Allele frequencies range from 1.5 to 35.7% and genotype observations do not deviate significantly from Hardy-Weinberg equilibrium; observed heterozygosity is 0.8238 with an allelic diversity value of 0.79 and the power of discrimination is 0.925. Our Italian population sample shows differences from other Caucasian samples both for allele and genotype frequencies. This locus typing for the 8 defined alleles provides a rapid and sensitive method in individual identification and paternity investigation.

引用

页码：59 / 66

页数：8

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