LOW-RESOLUTION REAL-SPACE ENVELOPES - AN APPROACH TO THE ABINITIO MACROMOLECULAR PHASE PROBLEM

被引：36
|
作者：
SUBBIAH, S
机构：
[1] Beckman Laboratories for Structural Biology, Department of Cell Biology, Stanford University School of Medicine, Stanford
来源：
SCIENCE | 1991年 / 252卷 / 5002期
关键词：
D O I：
10.1126/science.2011749
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
An ab initio approach to the phase problem in macromolecular x-ray crystallography is described. A random gas of hard-sphere point scatterers is allowed to condense under the constraint of the solvent fraction and the restraint of the observed Fourier amplitude data. Two applications to real macromolecular examples are discussed. This method produces an approximate outline of the bulk solvent regions and thus yields a low-resolution picture of the unit cell that can be extended to higher resolutions in special cases, such as through the use of molecular replacement or of noncrystallographic symmetry-based phase extension.
引用
收藏
页码：128 / 133
页数：6
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