MOLECULAR-CLONING AND SEQUENCING OF THE GENE ENCODING HUMAN ANGIOTENSIN-II TYPE-1 RECEPTOR

被引：154
|
作者：
FURUTA, H
GUO, DF
INAGAMI, T
机构：
[1] Department of Biochemistry, Vanderbilt University School of Medicine, Nashville
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 183卷 / 01期
关键词：
D O I：
10.1016/0006-291X(92)91600-U
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The gene of human angiotensin II type 1 (AT1) receptor was isolated from a lymphocyte genomic library. The coding region of the human AT1 receptor gene was contained in a single exon coding segment of the gene indicating an intronless structure of the coding region. The amino acid sequence of human AT1 receptor deduced from its base sequence has 359 amino acids and showed a high degree of sequence identity to bovine and rat AT1 receptor sequences. Amino acid substitutions specific to the human AT1 receptor were mostly confined to the carboxy terminal half of the molecule. The seven-transmembrane domains are well-conserved in those sequences. © 1992.
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页码：8 / 13
页数：6
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