6-SUBSTITUTED 5-CHLORO-1,3-DIHYDRO-2H-IMIDAZO[4,5-B]PYRAZIN-2-ONES WITH HYPOTENSIVE ACTIVITY

被引:14
|
作者
JONES, JH [1 ]
HOLTZ, WJ [1 ]
CRAGOE, EJ [1 ]
机构
[1] MERCK SHARP & DOHME RES LABS,W POINT,PA 19486
关键词
D O I
10.1021/jm00263a029
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:537 / 542
页数:6
相关论文
共 50 条
  • [21] Synthesis of disubstituted imidazo[4,5-b]pyridin-2-ones
    Kuethe, JT
    Wong, A
    Davies, IW
    JOURNAL OF ORGANIC CHEMISTRY, 2004, 69 (22): : 7752 - 7754
  • [22] Synthesis of 1,3,4,7-tetranitrooctahydro-2H-imidazo[4,5-b]pyrazin-2-one
    Rudakov, GF
    Veselova, EV
    Zhilin, VF
    THEORY AND PRACTICE OF ENERGETIC MATERIALS, VOL IV, 2001, : 28 - 31
  • [23] INHIBITORS OF BLOOD-PLATELET CAMP PHOSPHODIESTERASE .3. 1,3-DIHYDRO-2H-IMIDAZO[4,5-B]QUINOLIN-2-ONE DERIVATIVES WITH ENHANCED AQUEOUS SOLUBILITY
    MEANWELL, NA
    DENNIS, RD
    ROTH, HR
    ROSENFELD, MJ
    SMITH, ECR
    WRIGHT, JJK
    BUCHANAN, JO
    BRASSARD, CL
    GAMBERDELLA, M
    GILLESPIE, E
    SEILER, SM
    ZAVOICO, GB
    FLEMING, JS
    JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (14) : 2688 - 2696
  • [24] A NOVEL SYNTHESIS OF A 1,3-DISUBSTITUTED 1,3-DIHYDRO-2H-IMIDAZO[4,5-b]PYRIDIN-2-ONE. APPLICATION TO GW808990 A CRF1 RECEPTOR ANTAGONIST
    Hayes, Jerome F.
    Popkin, Matthew E.
    HETEROCYCLES, 2010, 82 (01) : 297 - 303
  • [25] Synthesis of 1-and 3-substituted imidazo[4,5-b]pyridin-2-ones
    Yu. M. Yutilov
    N. N. Smolyar
    D. A. Lomov
    Russian Journal of Organic Chemistry, 2006, 42 : 897 - 900
  • [26] Synthesis of 1- and 3-substituted imidazo[4,5-b]pyridin-2-ones
    Yutilov, Yu. M.
    Smolyar, N. N.
    Lomov, A. A.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2006, 42 (06) : 897 - 900
  • [27] 2-[(4,5-Dihydro-4-phenylthiazol-2-yl)methyl]-3H-imidazo[4,5-b]pyridine
    Sun, YW
    Duan, GY
    Liu, JZ
    Meng, LJ
    Wang, JW
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2006, 62 : O1 - O2
  • [28] Synthesis of Imidazo[4,5-b]pyridines and Imidazo[4,5-b]pyrazines by Palladium Catalyzed Amidation of 2-Chloro-3-amino-heterocycles
    Rosenberg, Adam J.
    Zhao, Jinbo
    Clark, Daniel A.
    ORGANIC LETTERS, 2012, 14 (07) : 1764 - 1767
  • [29] Discovery of 1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-ones based novel, potent and PI3Kδ selective inhibitors
    Bahekar, Rajesh
    Dave, Bhushan
    Soman, Shubhangi
    Pater, Dipam
    Chopade, Rajendra
    Funde, Radhika
    Kumar, Jeevan
    Sachchidanand, S.
    Giri, Poonam
    Chatterjee, Abhijit
    Mahapatra, Jogeswar
    Vyas, Purvi
    Ghoshdastidar, Krishnarup
    Bandyopadhyay, Debdutta
    Desai, Ranjit C.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 29 (11) : 1313 - 1319
  • [30] Substituted imidazo[4,5-b]pyridin-2-ones and -thiones as inhibitors of coxsackie B3 replication
    Pürstinger, G
    Putzer, K
    Widmoser, M
    Padalko, E
    De Clercq, E
    Neyts, J
    ANTIVIRAL RESEARCH, 2004, 62 (02) : A79 - A79