Computational Approach to 3D Modeling of the Lymph Node Geometry

被引:25
|
作者
Kislitsyn, Alexey [1 ]
Savinkov, Rostislav [1 ]
Novkovic, Mario [2 ]
Onder, Lucas [2 ]
Bocharov, Gennady [3 ]
机构
[1] Moscow MV Lomonosov State Univ, Moscow 119991, Russia
[2] Kantonsspital St Gallen, Inst Immunobiol, CH-9007 St Gallen, Switzerland
[3] Russian Acad Sci, Inst Numer Math, Gubkina 8, Moscow 119333, Russia
来源
COMPUTATION | 2015年 / 3卷 / 02期
基金
俄罗斯科学基金会;
关键词
lymph node; FRC network; geometric model; computational method;
D O I
10.3390/computation3020222
中图分类号
O1 [数学];
学科分类号
0701 ; 070101 ;
摘要
In this study we present a computational approach to the generation of the major geometric structures of an idealized murine lymph node (LN). In this generation, we consider the major compartments such as the subcapsular sinus, B cell follicles, trabecular and medullar sinuses, blood vessels and the T cell zone with a primary focus on the fibroblastic reticular cell (FRC) network. Confocal microscopy data of LN macroscopic structures and structural properties of the FRC network have been generated and utilized in the present model. The methodology sets a library of modules that can be used to assemble a solid geometric LN model and subsequently generate an adaptive mesh model capable of implementing transport phenomena. Overall, based on the use of high-resolution confocal microscopy and morphological analysis of cell 3D reconstructions, we have developed a computational model of the LN geometry, suitable for further investigation in studies of fluid transport and cell migration in this immunologically essential organ.
引用
收藏
页码:222 / 234
页数:13
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